Effects of practolol on pressor responses to noxious stimuli in hypertensive patients.

Pressor responses to noxious stimuli in hypertensive patients. Effects of reserpine and chlorothiazide.

CLINICALi STUDIES of hypotensive drugs have been concerned primarily with the effects of these agents on basal or casual levels of blood pressure. Little attention has been given to alterations in the reactivity of the blood pressure to noxious stimuli during the course of chronie drug therapy. Persistent reactivity in treated patients is iiuplied fronm such data as those indicating that blood ...

Pressor Responses to Noxious Stimuli in Hypertensive Patients: Effects of Guanethidine Sulfate and Alpha Methyldopa.

Pressor Responses to Noxious Stimuli in Hypertensive Patients

IN previous studies, pressor reactivity to several standardized noxious stimuli was evaluated quantitatively, and increased responsiveness was demonstrated in hypertensive as compared with normotensive subjects." 2 The stimuli employed in these studies included simple psychologic provocation as well as the cold pressor test and the intravenous injection of a small dose of angiotensin II. Differ...

Studies in man on the relationship of adrenergic correlates to pressor responsivity.

THE PRESENT STUDY was undertaken as part of a continuing investigation of the mechanisms of cardiovascular responsiveness to noxious stimuli.' Its purpose was to determine (1) whether stimuli which raise blood pressure in man would produce concomitant changes in biochemical measures of activation of the autonomic nervous system, (2) whether such changes would vary with different stimuli, and (3...

Relationship between serum methadone concentration and cold pressor pain sensitivity in patients undergoing methadone maintenance therapy

Hyperalgesia is a common clinical phenomenon among opioid dependent patients on methadone maintenance therapy (MMT) and it may be associated with undertreated pain and/or therapeutic failure. This study aimed to investigate association between serum methadone concentration (SMC) and cold pressor pain responses. Cold pressor pain responses in 147 opioid dependent patients on MMT were assessed us...